Dopamine as a robust anchor to immobilize functional molecules on the iron oxide shell of magnetic nanoparticles |
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Authors: | Xu Chenjie Xu Keming Gu Hongwei Zheng Rongkun Liu Hui Zhang Xixiang Guo Zhihong Xu Bing |
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Institution: | Department of Chemistry, The Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China. |
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Abstract: | We report on the use of dopamine (DA) as a robust molecular anchor to link functional molecules to the iron oxide shell of magnetic nanoparticles. Using nitrilotriacetic acid (NTA) as the functional molecule, we created a system with an M/Fe2O3-DA-NTA (M = Co or SmCo5.2) nanostructure, which possesses high stability and specificity for separating histidine-tagged proteins. The well-established biocompatibility of iron oxide and the robust covalent bonds between DA and Fe2O3 render this strategy attractive for constructing biofunctional magnetic nanoparticles containing iron oxide. |
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