Enantioselective benzoylation of alpha-amino esters using (S)-1-benzoyl-2- (alpha-acetoxyethyl)benzimidazole, a chiral benzimidazolide |
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| Authors: | Karnik Anil V Kamath Suchitra S |
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| Institution: | Department of Chemistry, University of Mumbai, Vidyanagari, Santacruz (E), Mumbai 400098, India. avkarnik@chem.mu.ac.in |
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| Abstract: | A new chiral benzimidazolide is developed as a nonenzymatic acylating agent for enantioselective benzoylation of racemic alpha-amino esters. The process is highly efficient, which exhibits uniformly high enantioselectivity for alpha-amino esters with or without aryl substituents under mild reaction conditions. The chiral benzimidazolide is inexpensive and is easily accessible. |
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