Construction of quaternary centres for natural polycycles: The Pauson-Khand approach |
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Authors: | Eduardo Arná iz |
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Affiliation: | Departamento de Química, Facultad de Farmacia, Universidad San Pablo-CEU, Boadilla del Monte 28668-Madrid, Spain |
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Abstract: | Construction of quaternary carbons is a challenge in PK chemistry, with few precedents in the literature. Starting from suitable functionalized enynes including an aromatic ring that templates the reaction, polycyclic ketones are obtained with a quaternary carbon. Special reaction conditions are necessary including the use of molecular sieves and co-catalysis with rhodium complexes jointly with cobalt carbonyl. The products obtained are intermediates in the synthesis of various natural products like the Hamigeran family and the steroidic alkaloid Conessine. |
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Keywords: | Pauson-Khand Natural products Cyclizations Cobalt Rhodium |
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