Efficient Domino Approach to Polysubstituted 2‐Hydroxyindole‐3,4‐(2H,5H)‐diones |
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| Authors: | Yan Xiang Hai‐Wei Xu Wei Fan Bo Jiang Shu‐Jiang Tu |
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| Affiliation: | 1. Department of Pharmaceutical Engineering, Jiangsu Provincial Xuzhou Pharmaceutical Vocational College, Jiangsu, Xuzhou, People's Republic of China;2. School of Chemistry & Chemical Engineering, Jiangsu Normal University, Xuzhou, Jiangsu, People's Republic of China |
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| Abstract: | Concise and efficient domino [3 + 2] heterocyclization promoted by HCOOH has been established for unprecedented synthesis of 15 examples of 2‐hydroxyindole‐3,4‐(2H,5H)‐diones in good yields. The present methodology shows attractive properties such as mild reaction conditions, concise one‐pot operation, short reaction periods of 15–20 min, and easy purification. The resulting 2‐hydroxyindole‐3,4(2H,5H)‐diones are of importance for organic and medicinal research. |
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