Highly Regioselective and Diastereoselective,One‐Pot,Four‐Component Synthesis of Novel Spiroindenoquinoxalineindolizidine Derivatives |
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Authors: | Mehdi Moemeni Hamid Arvinnezhad Saadi Samadi Farbod Salahi Khosrow Jadidi Behrouz Notash |
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Institution: | Department of Chemistry, Faculty of Sciences, Shahid Beheshti University, Tehran, Iran |
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Abstract: | A one‐pot, four‐component procedure for the synthesis of novel spiroindenoquinoxalineindolizidines with high regioselectivity and diastereoselectivity from the 1,3‐dipolar cycloaddition of azomethine ylides, generated from indenoquinoxalines and pipecolinic acid, and chalcones is described. The reaction occurs under reflux of ethanol as a green solvent and in the absence of any catalyst. The cycloadducts are obtained purely without future purification. The regiochemistry and stereochemistry of resultant cycloadducts have been determined by several 2D‐NMR spectroscopic techniques and X‐ray single crystal diffraction. |
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