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Microwave‐assisted Synthesis of 6‐{(5‐Aryl‐1,3,4‐oxadiazol‐2‐yl)methyl}‐6H‐indolo[2,3‐b]quinoxalines
Authors:Sreenivas Avula  Jayaram Reddy Komsani  Satish Koppireddi  Rambabu Yadla
Institution:Fluoroorganic Division, CSIR‐Indian Institute of Chemical Technology, Hyderabad, India
Abstract:An efficient and convenient synthesis of a new series of 2‐{(6H‐indolo2,3‐b]quinoxalin‐6‐yl)methyl}‐5‐aryl‐1,3,4‐oxadiazoles from readily available 1,2‐diaminobenzene and isatins under microwave irradiation conditions was disclosed. The 6‐{(5‐aryl‐1,3,4‐oxadiazol‐2‐yl)methyl}‐6H‐indolo2,3‐b]quinoxalines were also prepared by the thermal cyclo‐condensation reaction of 2‐(6H‐indolo2,3‐b]quinoxalin‐6‐yl)acetohydrazides with carboxylic acids in refluxing POCl3. The microwave‐assisted synthesis was rapid and resulted in higher yield of the products at lower operating temperature with reduced waste generation in comparison with the thermal reaction protocol.
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