Synthesis of Novel 2‐Oxoquinoline Derivatives via Ugi‐Four‐Component‐Heck Reaction |
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| Authors: | Mohammad Ali Rasouli Mohammad Mahdavi Mina Saeedi Parviz Rashidi Ranjbar Abbas Shafiee Alireza Foroumadi |
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| Affiliation: | 1. School of Chemistry, University College of Science, University of Tehran, Tehran, Iran;2. Department of Medicinal Chemistry, Faculty of Pharmacy and Pharmaceutical Sciences Research Center, Tehran University of Medicinal Sciences, Tehran, Iran;3. Drug Design & Development Research Center, Tehran University of Medicinal Sciences, Tehran, Iran |
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| Abstract: | The present study provides an efficient strategy for the preparation of novel N‐substituted‐4‐methyl‐quinolin‐1(2H)‐one derivatives via two‐step Ugi/Heck reaction. The procedure is based on the Ugi coupling between 2‐bromoanilines, various aromatic aldehydes, vinylacetic acid, and isocyanides, and then intramolecular Heck reaction, which leads to the formation of the title compounds in good yields. |
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