Synthesis and In Vitro Antimicrobial Activity of 1,3,4‐Oxadiazole‐2‐thiol and its Analogs |
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| Authors: | R Galge A Raju M S Degani B N Thorat |
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| Institution: | 1. Department of Chemical Engineering, Institute of Chemical Technology, Mumbai, Maharashta, India;2. Department of Pharmaceutical Sciences and Technology, Institute of Chemical Technology, Mumbai, Maharashta, India |
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| Abstract: | The present communication deals with the synthesis of 1,3,4‐oxadiazole‐2‐thiol derivatives containing cyclic secondary amines such as morpholine, N‐methyl piperizine, and piperizine. The structural elucidation is based on the spectral data (IR, 1H NMR, and 13C NMR) .The newly synthesized compounds were then tested for their antimicrobial activity against a representative panel of micro‐organisms such as Bacillus subtilis, Escherichia coli and Candida albicans by using ciprofloxacin and fluconazole as reference drugs for bacteria and fungi, respectively. These synthesized compounds showed moderate to potential antibacterial and antifungal activity in the range of 6–50 μM against the selected bacteria and 12–50 μM against the most common fungi, respectively. |
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