Polycyclic N‐Heterocyclic Compounds. Part 85: Synthesis and Evaluation of Antiplatelet Aggregation Activity of 2,4‐Disubstituted 5,6‐Dihydro[1]benzazepino[5,4‐d]pyrimidine and Related Compounds |
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| Authors: | Kensuke Okuda Ying‐Xue Zhang Takashi Hirota Kenji Sasaki |
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| Affiliation: | 1. Laboratory of Medicinal and Pharmaceutical Chemistry, Gifu Pharmaceutical University, Gifu, Japan;2. Laboratory of Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, Okayama University, Okayama, Japan |
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| Abstract: | We have synthesized a large number of tricyclic 2‐substituted 4‐alkylamino‐5,6‐dihydro[1]benzazepino[5,4‐d]pyrimidines as part of our research to develop new effective antiplatelet drugs. A variety of alkyl and aryl groups were used as substituents at the 2‐position. Evaluation of the effects of the newly synthesized compounds on collagen‐induced platelet aggregation revealed several promising antiplatelet candidates with potencies superior to aspirin. |
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