A Three‐Component Reaction for the Efficient Construction of the 2′,11b′‐Dihydrospiro[indoline‐3,1′‐pyrido[2,1‐a]isoquinoline] Skeleton |
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| Authors: | Jing Sun Yan Sun Hui Gong Chao‐Guo Yan |
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| Institution: | College of Chemistry & Chemical Engineering, Yangzhou University, Yangzhou, China |
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| Abstract: | The three‐component reactions of isoquinoline, acetylenedicarboxylates, and 3‐phenacylideneoxindoles in ethanol at room temperature resulted in a mixture of two diastereoisomers of 2′,11b′‐dihydrospiroindoline‐3,1′‐pyrido2,1‐a]isoquinoline] derivatives, which were successfully separated and characterized. The regioselectivity and diastereoselectivity of this reaction were briefly discussed. |
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