Synthesis and Cytotoxic Activity of Some Novel Dihyrobenzo[h]pyrano[3,2‐c]chromene Derivatives |
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| Authors: | Nasim Esmati Mahsa Foroughian Mina Saeedi Mohammad Mahdavi Mehdi Khoshneviszadeh Omidreza Firuzi Nader Tanideh Ramin Miri Najmeh Edraki Abbas Shafiee Alireza Foroumadi |
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| Institution: | 1. Drug Design and Development Research Center, Tehran University of Medicinal Sciences, Tehran, Iran;2. Faculty of Pharmacy and Pharmaceutical Sciences Research Center, Tehran University of Medicinal Sciences, Tehran, Iran;3. Medicinal and Natural Product Chemistry Research Center, Shiraz University of Medical Sciences, Shiraz, Iran |
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| Abstract: | Three‐component reaction of 4‐hydroxy‐2H‐benzoh]chromen‐2‐one, aromatic aldehydes, and malononitrile in the presence of 1,4‐diazabicyclo2.2.2]octane (DABCO) in ethanol at room temperature affords good yields of novel dihyrobenzoh]pyrano3,2‐c]chromene derivatives. The synthesized compounds examined by MTT assays for cytotoxic activity in two human cancer cell lines (MOLT‐4, HL‐60). Most of the evaluated compounds showed low inhibitory activity against tumor cell line at micromolar concentrations. |
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