Synthesis and Antimicrobial Evaluation of Some New Spiroindolinone Derivatives |
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Authors: | Hala M Refat |
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Institution: | Chemistry Department, Faculty of Education, Suez Canal University, Al‐Arish, Egypt |
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Abstract: | In an attempt to find a new class of antimicrobial agents, a series of spiroindolinone compounds containing pyridine, pyrimidine, benzopyrans, pyrido, naphtodiazepines, pyrazole, and isoxazole ring systems were prepared via the reaction of 3‐(2‐oxo‐2‐(3‐oxo‐3H‐benzof]chromen‐2‐yl)ethylidene)indolin‐2‐one ( 4 ) with an appropriate nucleophilic reagent. Newly synthesized compounds were characterized by elemental analysis and spectral data (IR, 1H‐NMR, 13C‐NMR, and mass spectra). Representative compounds were tested and evaluated as antimicrobial agents. |
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