Copper‐catalyzed Cyclization of 3‐Acylcoumarin Hydrazone using Air as the Oxidant: Efficient Synthesis of Pyrazole‐Fused Coumarin Derivatives |
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| Authors: | Hui‐Yan Wang Xue‐Cheng Liu Zhi‐Bin Huang Da‐Qing Shi |
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| Institution: | 1. Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou, People's Republic of China;2. Department of Chemical Engineering, Huaihai Institute of Technology, Lianyungang, People's Republic of China |
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| Abstract: | An efficient, convenient Cu‐catalyzed formation of chromeno4,3‐c]pyrazol‐4(1H)‐ones is reported. In this atom economic process, readily available 3‐acylcoumarin hydrazone is oxidative cyclized by direct C–N bond formation. Air has been successfully used as an oxidant, which has important economic and environmental advantages. A broad scope of 3‐acylcoumarin hydrazones can be utilized in this process. |
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