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An Easy Access to Benzofurans via DBU Induced Condensation Reaction of Active 2‐Hydroxy Acetophenones with Phenacyl Chlorides: A Novel Class of Antioxidant Agents
Authors:J Rangaswamy  H Vijay Kumar  S T Harini  Nagaraja Naik
Institution:1. Department of Studies in Chemistry, University of Mysore, Mysore, India;2. Department of Organic Chemistry, Indian Institute of Science, Bangalore, India
Abstract:A convenient and efficient one‐pot synthesis of benzofurans 3a , 3b , 3c , 3d , 3e , 3f , 3g , 3h , 3i , 3j , 3k , 3l , 3m , 3n , 3o , 3p , 3q , 3r , 3s , 3t has been described from 2‐hydroxy acetophenones and phenacyl chlorides in the presence of DBU. The procedure was applicable for a variety of phenacyl chlorides and provides a variety of benzofurans with higher yields. DBU acts as a base and as well as nucleophiles. All the derivatives were subjected to in vitro antioxidant screenings against representative 2,2′‐diphenyl‐1‐picryl‐hydrazyl and 2,2′‐azino‐bis(3‐ethylbenzthiazoline‐6‐sulfonic acid) radicals and results worth for further investigations.
Keywords:
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