Two‐Step Synthesis of Multifunctional γ‐Lactams from γ‐Lactone |
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| Authors: | Feten Béji Sonia Taktouk Jihène Ben Kraïem Salem S. Al‐Deyab Hassen Amri |
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| Affiliation: | 1. Department of Chemistry, Faculty of Science, El Manar University, Tunis, Tunisia;2. Department of Chemistry, College of Science, King Saud University, Riaydh, Saudi Arabia |
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| Abstract: | We present herein an efficient and rapid method for the synthesis of N,1‐dialkyl‐4‐(2‐hydroxyethyl)‐5‐oxopyrrolidine‐3‐carboxamides based on the conversion of γ‐lactone to γ‐lactam via the conjugate addition of primary amines to an ethyl α‐functionalized acrylate followed by intramolecular cyclization. |
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