Chemistry of an Unexplored Heterocyclic Ring System: Versatile Synthesis of 5‐Aryl‐2,3,4‐benzothiadiazepine 2,2‐dioxides |
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| Authors: | József Fetter Ferenc Bertha Balázs Molnár Balázs Volk Gyula Simig |
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| Institution: | 1. Budapest University of Technology and Economics, Department of Organic Chemistry and Technology, Budapest, Hungary;2. Egis Pharmaceuticals Plc., Chemical Research Division, Budapest, Hungary |
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| Abstract: | The article gives insight into the synthetic approach of a practically new heterocyclic ring system, 2,3,4‐benzothiadiazepines. Starting from the easily available phthalides, an efficient synthesis of 5‐aryl‐2,3,4‐benzothiadiazepine 2,2‐dioxides is described here. Owing to their close structural similarity to 2,3‐benzodiazepines and 2,3‐benzodiazepine‐4‐ones, two well‐known bioactive compound families, the new derivatives can be of importance in medicinal chemistry. |
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