A Facile One‐Step Synthesis of 2‐Arylindazoles via Reductive Cyclization of N‐(2‐nitroarylidene)amines |
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| Authors: | Wei Lin Minghua Hu Xian Feng Chengpao Cao Zhibin Huang Daqing Shi |
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| Institution: | Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou, People's Republic of China |
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| Abstract: | A mild and efficient synthesis of 2‐arylindazole derivatives via the reductive cyclization of nitro‐aryl substrates mediated by a low‐valent titanium reagent (TiCl4/Sm/Et3N) has been developed. The attractive features of the current method include an N–N bond formation and the selective reduction of the C = N bond and nitro group, both of which were easily achieved in one‐pot by controlling the pH of the reaction mixture. |
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| Keywords: | synthesis 2‐aryl‐indazole |
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