Green Biginelli‐type Reaction: Solvent‐free Synthesis of 5‐unsubstituted 3,4‐dihydropyrimdin‐2(1H)‐ones |
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| Authors: | Min Wang Jilei Song Qilin Lu Qinglin Wang |
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| Institution: | College of Chemistry, Chemical Engineering and Food Safety, Bohai University, Jinzhou, China |
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| Abstract: | The Biginelli‐type compounds, 5‐unsubstituted 3,4‐dihydropyrimdin‐2(1H)‐ones were synthesized by a one‐pot three‐component condensation of aromatic aldehydes, aromatic ketones and urea in the presence of SnCl4 · 5H2O under solvent‐free conditions. The advantages of this method are short reaction time (4–10 min), excellent yields (74–97%), inexpensive catalyst and solvent‐free conditions. A plausible mechanism was proposed. |
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| Keywords: | Biginelli‐type reaction One‐pot synthesis Tin tetrachloride Solvent‐free condition |
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