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Green Biginelli‐type Reaction: Solvent‐free Synthesis of 5‐unsubstituted 3,4‐dihydropyrimdin‐2(1H)‐ones
Authors:Min Wang  Jilei Song  Qilin Lu  Qinglin Wang
Institution:College of Chemistry, Chemical Engineering and Food Safety, Bohai University, Jinzhou, China
Abstract:The Biginelli‐type compounds, 5‐unsubstituted 3,4‐dihydropyrimdin‐2(1H)‐ones were synthesized by a one‐pot three‐component condensation of aromatic aldehydes, aromatic ketones and urea in the presence of SnCl4 · 5H2O under solvent‐free conditions. The advantages of this method are short reaction time (4–10 min), excellent yields (74–97%), inexpensive catalyst and solvent‐free conditions. A plausible mechanism was proposed.
Keywords:Biginelli‐type reaction  One‐pot synthesis  Tin tetrachloride  Solvent‐free condition
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