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Anti-NLRP3 inflammasome abietane diterpenoids from Callicarpa bodinieri and their structure elucidation |
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| Authors: | Junbo Gao Xingjie Zhang Kun Shang Weimao Zhong Ruihan Zhang Xiaochang Dai Xiaoli Li Qi Wang Yan Zou Weilie Xiao |
| Institution: | Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education and Yunnan Province, School of Chemical Science and Technology, Yunnan University, Kunming 650091, China; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China |
| Abstract: | Callicarpa bodinieri is a Chinese traditional medicine herbwith anti-inflammatory activity in clinic. Herein, we report two new 9,10-seco and etherified abietane diterpenoids bodinieric acids J and K(1 and 2)and one known compound (3) isolated from the leaves and twigs of this plant. Their chemical structures were elucidated by detailed spectrometry data analysis and DP4+ NMR calculation methods. Hypothetical biosynthetic pathways of 1-3 were preliminarily speculated. Compound 3 inhibited inflammasome activation and exhibited blockage of NLRP3 inflammasome activation at non-cytotoxic concentrations in vitro. |
| Keywords: | Callicarpa bodinieri Abietane-type diterpenoids DP4+ NMR calculation Anti-inflammation Pyroptosis NLRP3 inflammasome |
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