| 1,2-Dibromoethane and KI mediated α-acyloxylation of ketones with carboxylic acids |
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| 作者姓名： | Xujie Wang Gangsheng Li Yanan Yang Jianshuang Jiang Ziming Feng Peicheng Zhang |
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| 作者单位： | State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China |
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| 基金项目： | We are grateful to the Drug Innovation Major Project (No. 2018ZX09711001-001-001) andCAMS Innovation Fund for Medical Sciences (CIFMS) (No. 2016-I2M-1-010) for financial support. |
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| 摘 要： | The 1,2-dibromoethane-and Kl-mediatedα-acyloxylation of ketones is reported in moderate to good yield without the use of transition metals and strong oxidants.Various acids are well tolerated with wide functional group compatibility.An 1,2-dibromoethane-and Kl-catalysed reaction mechanism is proposed based on the results of control experiments.
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| 关 键 词： | 1 2-Dibromoethane KI α-Acyloxylation KETONES Carboxylic ACIDS |
| 收稿时间： | 13 July 2019 |
1,2-Dibromoethane and KI mediated α-acyloxylation of ketones with carboxylic acids |
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| Xujie Wang,Gangsheng Li,Yanan Yang,Jianshuang Jiang,Ziming Feng,Peicheng Zhang.1,2-Dibromoethane and KI mediated α-acyloxylation of ketones with carboxylic acids[J].Chinese Chemical Letters,2020,31(3):711-714. |
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| Authors: | Xujie Wang Gangsheng Li Yanan Yang Jianshuang Jiang Ziming Feng Peicheng Zhang |
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| Institution: | State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China |
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| Abstract: | The 1,2-dibromoethane-and KI-mediated α-acyloxylation of ketones is reported in moderate to good yield without the use of transition metals and strong oxidants. Various acids are well tolerated with wide functional group compatibility. An 1,2-dibromoethane-and KI-catalysed reaction mechanism is proposed based on the results of control experiments. |
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| Keywords: | 1 2-Dibromoethane KI α-Acyloxylation Ketones Carboxylic acids |
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