| Seven-step total synthesis of α-cyclopiazonic acid |
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| 作者姓名： | Shibin Shi Kuo Yuan Yanxing Jia |
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| 作者单位： | State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China |
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| 基金项目： | This research was supported by the National Natural Science Foundation of China (No. 21871013) and the Drug Innovation Major Project (No. 2018ZX09711-001-005-005). |
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| 摘 要： | A seven-step total synthesis of α-cyclopiazonic acid is reported from a commercially available 4-bromoindole.Salient feature of the work is the rapid formation of tetracyclic skeleton via a bioinspired 3+2] annulation to form the C/D rings.
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| 关 键 词： | INDOLE ALKALOIDS TOTAL synthesis CASCADE CYCLIZATION NATURAL products |
| 收稿时间： | 12 May 2019 |
Seven-step total synthesis of α-cyclopiazonic acid |
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| Shibin Shi,Kuo Yuan,Yanxing Jia.Seven-step total synthesis of α-cyclopiazonic acid[J].Chinese Chemical Letters,2020,31(2):401-403. |
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| Authors: | Shibin Shi Kuo Yuan Yanxing Jia |
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| Institution: | State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China |
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| Abstract: | A seven-step total synthesis of α-cyclopiazonic acid is reported from a commercially available 4-bromoindole. Salient feature of the work is the rapid formation of tetracyclic skeleton via a bioinspired 3+2] annulation to form the C/D rings. |
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| Keywords: | Indole alkaloids Total synthesis Cascade cyclization Natural products |
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