Fabrication of doxorubicin and chlorotoxin-linked Eu-Gd2O3 nanorods with dual-model imaging and targeted therapy of brain tumor |
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Authors: | Weina Zhang Zhongbing Huang Ximing Pu Xianchun Chen Guangfu Yin Lei Wang Fei Zhang Fabao Gao |
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Institution: | College of Materials Science and Engineering, Sichuan University, Chengdu 610065, China; Molecular Imaging Center, Department of Radiology, West China Hospital of Sichuan University, Chengdu 610093, China |
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Abstract: | It is urgent to find a technology accurately to better diagnose and treat to brain tumor. Eu-doped Gd2O3 nanorods (Eu-Gd2O3 NRs) with paramagnetic and fluorescent properties were conjugated with doxorubicin (Dox) and chlorotoxin (CTX) via PEGylation, hydrazone bond and sulfur bond (named as CTXNRs-Dox), and these NRs could release more Dox in lower pH environment. The results of cell experiments indicated that CTX-NRs-Dox had obvious targeting and toxic effects on U251 cells, as well as good fluorescence imaging behavior. The orthotopic glioma-transplanted mice models were constructed via the intracranial injection of glioma cells (U87MG). The result of experiments after the tail-vein injection of the prepared NRs suggested that CTX-NRs-Dox could target to brain tumors via the long-time blood circulation, leading to their obvious contrast enhancement of MR imaging of the intracranial tumor and their significant inhibitory effect on the growth and metastasis of brain tumors. A mechanism of synergistic effect of CTX-NRs-Dox on targeting and inhabiting the brain tumor was proposed. Our research suggested that CTX-NRs-Dox had potential application prospect in the detection and treatment of glioma. |
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Keywords: | Brain tumor Dual-model imaging Doxorubicin Chlorotoxin Eu-Gd2O3 nanorods Targeted therapy |
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