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Asymmetric synthesis of pyrrolo[1,2-a]indoles via organocatalytic[3 + 2] annulation of substituted 2-vinylindoles with azlactones |
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| Authors: | Wulin Yang Hao Wang Zirong Pan Zhong Li Weiping Deng |
| Institution: | Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China; Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China; Shanghai Collaborative Innovation Center for Biomanufacturing Technology, Shanghai 200237, China |
| Abstract: | The chiral phosphoric acid catalyzed asymmetric3 + 2] annulation of substituted 2-vinylindoles with azlactones has been established. This reaction represented a practical approach for the synthesis of structurally diverse pyrrolo1,2-a]indoles with two vicinal stereocenters including one tetrasubstituted stereocenter in good yields and good stereoselectivities under mild conditions. |
| Keywords: | [3 + 2] Annulation Azlactones 2-Vinylindoles Asymmetric organocatalysis Pyrrolo[1 2-a]indoles Chiral phosphoric acid |
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