| 烯胺酮与烯胺酯的交叉缩合反应 |
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| 引用本文： | 康国钧,卓金聪,龙玛,高振衡,章本礼. 烯胺酮与烯胺酯的交叉缩合反应[J]. 有机化学, 1988, 8(1): 23-28 |
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| 作者姓名： | 康国钧 卓金聪 龙玛 高振衡 章本礼 |
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| 作者单位： | 南开大学化学系 天津 |
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| 摘 要： | 在三氟乙酸(TFA)作用下,烯胺酮(1)与烯胺酯(7或2)的[3C十3C]交叉缩合反应,主要形成2-胺基-4,6-二甲基苯甲酸甲酯(5)。讨论了三氟乙酸用最及不同的烯胺酮对[3C+3C]缩合反应中3的收率和产物分配的影响。烯胺酮在三氟乙酸作用下,可在温和的条件下自缩合,产物易于纯化。
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| 关 键 词： | 烯胺酮 烯胺酯 交叉缩合反应 |
Study on Cross-condensation of Enamino-ketones with Enamino-esters |
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| KANG Guo-Jun ZHUO Jin-Cong LONG Ma GAO Zhen-Heng ZHANG Ben-Li. Study on Cross-condensation of Enamino-ketones with Enamino-esters[J]. Chinese Journal of Organic Chemistry, 1988, 8(1): 23-28 |
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| Authors: | KANG Guo-Jun ZHUO Jin-Cong LONG Ma GAO Zhen-Heng ZHANG Ben-Li |
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| Affiliation: | KANG Guo-Jun ZHUO Jin-Cong LONG Ma GAO Zhen-Heng ZHANG Ben-Li~* |
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| Abstract: | The[3C+3C]cross-condensation reactions of enamino-ketones(1)withenamino-esters(7 or 2)in the presence of trifluoroacetic acid(TFA)gave methyl-2-amino-4,6-dimethyl benzoates(3)as main product.The effects of the amount of TFAand the structure of 1 on the yields of 3 and the product distribution were determined.Under mild condition,the products of the self-condensation reactions of enamino-ketonesby the action of TFA were simpler and could be easily purified. |
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| Keywords: | enamino-ketones enamino-esters cross-condensation |
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