| 4-硫脱氧胸苷及类似物在UVA光辅助治疗抗癌药物方面的研究 |
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| 引用本文： | 张晓辉,王爱玲,李德鹏,徐耀忠.4-硫脱氧胸苷及类似物在UVA光辅助治疗抗癌药物方面的研究[J].化学进展,2010,22(5):784-795. |
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| 作者姓名： | 张晓辉 王爱玲 李德鹏 徐耀忠 |
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| 作者单位： | (1. 大连大学环境与化学工程学院 大连 116622; 2. Department of Chemistry and Analytical Sciences, The Open University, Walton Hall, Milton Keynes MK7 6AA, UK) |
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| 摘 要： | 本文叙述了含硫碱基DNA的化学和医疗应用。硫碱基（Thio-base）有其独特的性质，比如，易烷基化,易氧化和强的紫外长波(400-315 nm，UVA)吸收。这些特定化学和物理性质存于含硫碱基、含硫核苷和含硫碱基DNA中，它们对制备修饰的DNA和对硫碱基的DNA与其它生物大分子之间进行光诱导的交联反应是非常有用的。功能化的含有硫碱基的DNA及其类似物可用于对DNA的修复的研究。本文也介绍和评述了利用紫外光/含硫脱氧胸（腺嘧啶脱氧核）苷（UVA/Thiothymidine）的抗癌疗法，同时，探讨了含硫核苷类似物和紫外线光之间的协同作用，为癌症和其它疾病治疗提供一种新的方法。
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| 关 键 词： | 4-硫脱氧胸苷 改性碱基 DNA 修复 抗癌药物 光动力疗法（PDT) |
| 收稿时间： | 2009-10-14 |
| 修稿时间： | 2009-12-10 |
UVA Light-Assisted Anticancer Drugs---Study on 4-Thiothymidine & Its Analogues |
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| Zhang Xiaohui Wang Ailing Li Depeng Xu Yaozhong.UVA Light-Assisted Anticancer Drugs---Study on 4-Thiothymidine & Its Analogues[J].Progress in Chemistry,2010,22(5):784-795. |
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| Authors: | Zhang Xiaohui Wang Ailing Li Depeng Xu Yaozhong |
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| Institution: | (1. College of Environment and Chemical Engineering, Dalian University, Dalian 116622, China; 2. Department of Chemistry and Analytical Sciences, The Open University, Walton Hall, Milton Keynes MK7 6AA, UK) |
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| Abstract: | The article reviews the chemical methods for the preparation of DNA containing 4-thiothymine. 4-Thiothymine has several unique properties,such as easy alkylation,ready oxidation and strong absorption in UVA region. These chemical and physical properties are retained at its nucleoside and DNA levels and particularly useful for chemical manipulation and photo crossing of the thiothymine DNA with other biomolecules of interest. The ability to make DNA containing thiothymine or their functionalized analogues is... |
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| Keywords: | thiothymidine modified bases DNA repair anticancer drugs photodynamic therapy (PDT) |
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