Chemical synthesis of picornaviral protein primers of RNA replication |
| |
| Authors: | Kriek Nicole M A J Meeuwenoord Nico J van den Elst Hans Heus Hans A van der Marel Gijsbert A Filippov Dmitri V |
| |
| Affiliation: | Leiden Institute of Chemistry, Leiden University, PO Box 9502, 2300, RA Leiden, The Netherlands. |
| |
| Abstract: | Naturally occurring nucleopeptidic replication primers (VPg-pUpU) of poliovirus and coxsackie virus were chemically synthesized. The synthesis was accomplished via block-coupling of two minimally protected fragments of the target structures: a short RNA-nucleopeptide and a longer peptide segment containing diverse side-chain functionalities. The synthetic VPg-pUpU of coxsackie virus was characterized by NMR spectroscopy. |
| |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ |
|
