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| 99mTc水杨醛Schiff碱配合物的制备与生物分布 | |
| 引用本文： | 王明召,孟昭兴,彭安,谭信. 99mTc水杨醛Schiff碱配合物的制备与生物分布[J]. 高等学校化学学报, 2005, 26(5): 816-818 |
| 作者姓名： | 王明召 孟昭兴 彭安 谭信 |
| 作者单位： | 1. 放射性药物教育部重点实验室,北京师范大学化学系,北京,100875 2. 北京师范大学生命科学学院,北京,100875 3. 北京理工大学生命科学与技术学院,北京,100081 |
| 基金项目： | 国家自然科学基金;教育部重点实验室基金 |
| 摘 要： | One novel complex of ^99mTc-salicylidene-tyrosine Schiff base was designed and synthesized, and its biodistribution was investigated. The theoretical simulation revealed that the cis- and trans-isomers might co-exist in aqueous solution. A yield higher than 90% under the optimal condition of synthesis was obtained. Good water-solubility was demonstrated. Very little uptakes in muscle, brain, heart and S-180 sarcoma, as well as very rapid blood clearance were revealed in mice. Good accumulation in bone was shown. At 1h postinjection the bone uptake was 10.9% ID/g. At 3 and 5h postinjection, bone-to-muscle ratios were 19.0 and 9.3, and bone-to-blood ratios were 31.6 and 28. 9, respectively. The result indicates a bone imaging potency of the complex. |
| 关 键 词： | 99mTc 水杨醛酪氨酸Schiff碱配合物 合成 生物分布 |
| 文章编号： | 0251-0790(2005)05-0816-03 |
| 收稿时间： | 2005-01-05 |
Synthesis and Biodistribution of 99mTc Salicylidene Schiff Base Complex |
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| WANG Ming-zhao,MENG Zhao-xing,PENG An,TAN Xin. Synthesis and Biodistribution of 99mTc Salicylidene Schiff Base Complex[J]. Chemical Research In Chinese Universities, 2005, 26(5): 816-818 | |
| Authors: | WANG Ming-zhao MENG Zhao-xing PENG An TAN Xin |
| Affiliation: | 1. Key Laboratory of Radiopharmaceuticals, Ministry of Education, Department of Chemistry, Beijing Normal University, Beijing 100875, China; 2. College of Life Sciences, Beijing Normal University, Beijing 100875, China; 3. School of Life Sciences and Technology, Institute of Beijing Technology, Beijing 100081, China |
| Abstract: | One novel complex of ()~(99m)Tc-salicylidene-tyrosine Schiff base was designed and synthesized, and its biodistribution was investigated. The theoretical simulation revealed that the cis- and trans-(isomers) might co-exist in aqueous solution. A yield higher than 90% under the optimal condition of synthesis was obtained. Good water-solubility was demonstrated. Very little uptakes in muscle, brain, heart and S-180 sarcoma, as well as very rapid blood clearance were revealed in mice. Good accumulation in bone was shown. At 1 h postinjection the bone uptake was 10.9%ID/g. At 3 and 5 h postinjection, bone-to-muscle ratios were 19.0 and 9.3, and bone-to-blood ratios were 31.6 and 28.9, respectively. The result indicates a bone imaging potency of the complex. |
| Keywords: | 99mTc |
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