Developmental and neurochemical features of cholinergic neurons in the murine cerebral cortex |
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Authors: | Silvia Consonni Silvia Leone Andrea Becchetti Alida Amadeo |
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Affiliation: | (1) Department of Biotechnology and Biosciences, Piazza della Scienza 2, University of Milano, Bicocca, 20126 Milano, Italy;(2) Department of Biomolecular Sciences and Biotechnology, Via Celoria 26, University of Milano, 20133 Milano, Italy |
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Abstract: | Background The existence and role of intrinsic cholinergic cells in the cerebral cortex is controversial, because of their variable localization and morphology in different mammalian species. We have applied choline acetyltransferase (ChAT) immunocytochemistry to study the distribution of cholinergic neurons in the murine cerebral cortex, in the adult and during postnatal development. For more precise neurochemical identification of these neurons, the possible colocalization of ChAT with different markers of cortical neuronal populations has been analyzed by confocal microscopy. This method was also used to verify the relationship between cholinergic cells and cortical microvessels. |
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