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On the detection of multiple-binding modes of ligands to proteins,from biological,structural, and modeling data |
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| Authors: | Lewi Paul J de Jonge Marc Daeyaert Frits Koymans Luc Vinkers Maarten Heeres Jan Janssen Paul A J Arnold Eddy Das Kalyan Clark Art D Hughes Stephen H Boyer Paul L de Béthune Marie-Pierre Pauwels Rudi Andries Koen Kukla Mike Ludovici Donald De Corte Bart Kavash Robert Ho Chih Lewis Paul J |
| Institution: | (1) Center for Molecular Design, J&JPRD, Janssen Pharmaceutica N.V, Vosselaar, Belgium;(2) Center for Biotechnology and Medicine, and Chemistry and Chemical Biology Department, Rutgers University, NJ, USA;(3) NIH-NCI HIV Drug Resistance Program, Frederick, MD, USA;(4) Tibotec-Virco, Mechelen, Belgium;(5) Virology Dept., J&JPRD, Janssen Pharmaceutica N.V, Beerse, Belgium;(6) Chemistry Dept., J&JPRD, Spring House, PA, USA |
| Abstract: | |
| Keywords: | molecular modeling virology HIV X-ray crystallography drug design statistical analysis PLS |
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