Spirocyclization strategy toward indole phytoalexins. The first synthesis of (±)-1-methoxyspirobrassinin, (±)-1-methoxyspirobrassinol, and (±)-1-methoxyspirobrassinol methyl ether期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

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Spirocyclization strategy toward indole phytoalexins. The first synthesis of (±)-1-methoxyspirobrassinin, (±)-1-methoxyspirobrassinol, and (±)-1-methoxyspirobrassinol methyl ether

Authors:	Peter Kutschy Mojm&#x;&#x;r Suchý Kenji Monde Nobuyuki Harada Renata Maru&#x;kov Zuzana urillov Milan Dzurilla Mariana Miklo&#x;ov Roman Mezencev Jn Moji&#x;

Institution:	^aInstitute of Chemical Sciences, Faculty of Science, P. J. Šafárik University, Moyzesova 11, 041 67 Košice, Slovak Republic ^bDivision of Biological Sciences, Graduate School of Science, Hokkaido University, Kita 10, Nishi 8, Sapporo 060-0810, Japan ^cInstitute of Multidisciplinary Research for Advanced Materials, 2-1-1, Katahira, Aoba-ku, Sendai 980-8577, Japan ^dInstitute of Pharmacology, Faculty of Medicine, P. J. Šafárik University, SNP 1, 040 66 Košice, Slovak Republic

Abstract:	The first syntheses of cruciferous indole phytoalexins (±)-1-methoxyspirobrassinin, (±)-1-methoxyspirobrassinol, (±)-1-methoxyspirobrassinol methyl ether as well as a new syntheses of phytoalexins (±)-spirobrassinin and cyclobrassinin were achieved by dioxane dibromide (DDB)-mediated spirocyclization of brassinin and its 1-substituted derivatives.

Keywords:	phytoalexins indoles dioxane dibromide spirocyclization antitumor activity
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