Oxidative iodination of carbonyl compounds using ammonium iodide and oxone® |
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Authors: | Mahender Reddy MarriArun Kumar Macharla Swamy PerakaNarender Nama |
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Affiliation: | I&PC Division, Indian Institute of Chemical Technology, Hyderabad 500 007, India |
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Abstract: | A simple, efficient, mild, and regioselective method for oxyiodination of carbonyl compounds has been reported by using NH4I as the source of iodine and Oxone® as an oxidant. Various carbonyl compounds such as aralkyl ketones, aliphatic ketones (acyclic and cyclic), and β-keto esters proceeded to the respective α-monoiodinated products in moderate to excellent yields. Unsymmetrical aliphatic ketones reacted smoothly yielding a mixture of 1-iodo and 3-iodo ketones with the predominant formation of 1-iodoproduct. |
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Keywords: | α-Iodination Aralkyl ketones β-Keto esters Regioselectivity |
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