The Hummel-Dreyer method: impact in pharmacology |
| |
Authors: | Soltés Ladislav |
| |
Institution: | Institute of Experimental Pharmacology, Slovak Academy of Sciences, Dúbravská cesta 9, SK-84104 Bratislava, Slovak Republic. exfasolt@savba.sk |
| |
Abstract: | Reviews devoted to drug-protein binding present mostly a variety of analytical methods applied to studying the unique process when the protein reversibly binds a low-molecular-weight substance-the drug. This report, however, reviews the great majority of papers presenting the application of one particular method introduced by Hummel and Dreyer in 1962: Measurement of protein-binding phenomena by gel filtration. The main criterion in reviewing published papers was the application of the Hummel-Dreyer method when the counterpart substances were the drug and the human plasma protein. |
| |
Keywords: | chromatography capillary electrophoresis drugs drug–protein binding interaction reviews |
本文献已被 PubMed 等数据库收录! |
|