Positive ion electrospray ionization mass spectrometry of oligonucleotides |
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| Authors: | Kristin A Sannes-Lowery David P Mack Peifeng Hu Houng-Yau Mei Joseph A Loo |
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| Institution: | 1. Parke-Davis Pharmaceutical Research, Division of Warner-Lambert Company, Ann Arbor, Michigan, USA
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| Abstract: | Positive ion electrospray ionization mass spectra have been obtained of deoxyribonucleic acids (DNA) and ribonucleic acids (RNA), including transfer RNAs (77-mer, ～ 25 kDa). For several different solution conditions, the charge state distributions of DNA and RNA molecules were determined. It is postulated that the production of the multiply charged positive ions results from gas phase dissociation of complexes between nitrogen-containing bases and oligonucleotides. |
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