| 大叶橐吾中三个新的艾里莫芬型倍半萜 |
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| 引用本文： | 沈彤,李平林,袁呈山,贾忠建. 大叶橐吾中三个新的艾里莫芬型倍半萜[J]. 化学学报, 2007, 65(16): 1638-1642 |
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| 作者姓名： | 沈彤 李平林 袁呈山 贾忠建 |
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| 作者单位： | 兰州大学化学化工学院,功能有机分子化学国家重点实验室,兰州,730000;兰州大学化学化工学院,功能有机分子化学国家重点实验室,兰州,730000;兰州大学化学化工学院,功能有机分子化学国家重点实验室,兰州,730000;兰州大学化学化工学院,功能有机分子化学国家重点实验室,兰州,730000 |
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| 摘 要： | 从大叶橐吾的根部分离得到三个新的艾里莫芬型倍半萜(1, 2和3), 经多种波谱方法和单晶X射线衍射确定它们的结构分别为: 6α,15β-环氧-8β-羟基-艾里莫芬-7(11)-烯-8α,12-内酯(1), 7-乙酰基-13β-羧酸-6(7)-烯-降-艾里莫芬烷(2), 艾里莫芬-7(11)-烯-6α,15β-内酯(3). 此外, 对化合物1进行了抗菌和抗癌活性测试.
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| 关 键 词： | 大叶橐吾 菊科 艾里莫芬型倍半萜 单晶X射线衍射 |
| 收稿时间： | 2007-04-04 |
| 修稿时间： | 2007-04-042007-07-11 |
Three New Eremophilane-Type Sesquiterpenes from Ligularia macrophylla |
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| SHEN,Tong,LI,Ping-Lin,YUAN,Cheng-Shan,JIA,Zhong-Jian. Three New Eremophilane-Type Sesquiterpenes from Ligularia macrophylla[J]. Acta Chimica Sinica, 2007, 65(16): 1638-1642 |
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| Authors: | SHEN Tong LI Ping-Lin YUAN Cheng-Shan JIA Zhong-Jian |
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| Affiliation: | State Key Laboratory of Applied Organic Chemistry,College of Chemistry and Chemical Engineering,Lanzhou University,Lanzhou 730000 |
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| Abstract: | Three new eremophilane-type sesquitererpenes (1, 2 and 3) were isolated from the roots of Ligularia macrophylla. On the basis of spectroscopic methods including 2D NMR and X-ray diffraction experiment, their structures were elucidated as 6α,15β-epoxy-8β-hydroxy-7(11)-8α,12-olide (1), 7-acetyl-6(7)-en-nor- eremophil-13β-carboxylic acid (2) and eremophil-7(11)-en-6α,15β-olide (3). In addition, antibacterial activity and cytotoxicity activity of compound 1 were tested. |
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| Keywords: | Ligularia macrophylla Compositae eremophilane-type sesquiterpene X-ray diffraction |
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