短柄雪胆中的三萜葫芦素及其皂苷

从短柄雪胆的块根中分离得到了14个三萜葫芦素类化合物. 经波谱分析及化学方法鉴定了它们的结构, 其中有新化合物5个, 分别命名为短柄雪胆苷A～E (1～5), 以及肉花雪胆苷元A (6), 藤三七雪胆苷R8 (7), 肉花雪胆苷I (8), 肉花雪胆苷II (9), 肉花雪胆苷III (10), 雪胆甲素(11), 雪胆乙素(12), 雪胆甲素苷(13), 藤三七雪胆苷R1 (14)等9个已知化合物. 6是首次从自然界中得到的化合物.

Chemical Constituents from the Tubers of Hemsleya delavayi

Fourteen cucurbitane compounds, including five new ones named delavanosides A～E (1～5), and nine known ones identified as carnosiflogenin A (6), scandenoside R8 (7), carnosifloside I (8), carnosifloside II (9), carnosifloside III (10), hemslecin A (11), hemslecin B (12), 2-O-β-D-glycoside of hemslecin A (13) and scandenoside R1 (14), were isolated from the tubers of Hemsleya delavayi. On the basis of spectral analysis and chemical methods, the new compounds were elucidated as 3β,27-dihydroxycucurbita-5,24-dien- 11-on-27-O-β-D-glucopyranosyl(1®2)-β-D-glucopyranoside (1), 3β,20,27-trihydroxycucurbita-5,24-dien- 11-on-27-O-β-D-glucopyranosyl(1®2)-b-D-glucopyranoside (2), 3β,20,27-trihydroxycucurbita-5,24-dien- 11-on-3-O-β-D-glucopyranosyl-27-O-β-D-glucopyranosyl(1®2)-β-D-glucopyranoside (3), 3β,26-dihydroxy- cucurbita-5,24-dien-11-on-3-O-β-D-glucopyranoside (4) and 3β,26-dihydroxycucurbita-5,24-dien-11-on-3- O-β-D-glucopyranosyl-26-O-β-D-glucopyranosyl(1®6)-β-D-glucopyranosyl(1®2)-β-D-glucopyranoside (5). Compound 6 was also firstly isolated as a natural product.