Stability studies on nifedipine tablets using thermogravimetry and differential scanning calorimetry |
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| Authors: | R O C Filho P I B M Franco E C Conceição M I G Leles |
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| Institution: | 1. LAMES – Laboratório de Métodos de Extra??o e Separa??o, Instituto de Química, Universidade Federal de Goiás – UFG, Campus Samambaia, CEP 74001-970, Goiania, GO, Brazil
2. Faculdade de Farmácia, Universidade Federal de Goiás – UFG, Av. Universitária com 1a Avenida, S/N, CEP 74605-220, Goiania, GO, Brazil
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| Abstract: | A new formulation of nifedipine tablets was prepared. The tablets were conditioned in amber-colored glass containers and placed in a climatized room at 40 °C and relative humidity of 75% for 180 days. Differential scanning calorimetry (DSC) and Thermogravimetry (TG) were used in order to evaluate the thermal properties of nifedipine, the excipients and two well-known nifedipine degradation products. There is no evidence of interaction between nifedipine and excipients or degradation products. High performance liquid chromatography (HPLC) was used in the dosage of nifedipine tablets before and after acclimatized exposure. Results show that DSC and TG offer important data for a more detailed assessment of the stability of a pharmaceutical formulation. |
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