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Inhibition of O-GlcNAcase by a gluco-configured nagstatin and a PUGNAc-imidazole hybrid inhibitor |
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| Authors: | Shanmugasundaram Bhagavathy Debowski Aleksandra W Dennis Rebecca J Davies Gideon J Vocadlo David J Vasella Andrea |
| Affiliation: | Laboratorium für Organische Chemie, HCI H 317, ETH Zürich, CH-8093 Zürich, Switzerland. vasella@org.chem.ethz.ch |
| Abstract: | Synthesis of a PUGNAc-imidazole hybrid and its characterization as an inhibitor of human O-GlcNAcase through enzyme kinetics and X-ray structural analysis. |
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