| Synthesis of tanshinone ⅡA analogues and their inhibitory activities against Cdc25 phosphatases |
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| 引用本文： | Wei Gang Huang,Jing Ya Li,Yu Luo,Jia Li,Wei Lu. Synthesis of tanshinone ⅡA analogues and their inhibitory activities against Cdc25 phosphatases[J]. 中国化学快报, 2009, 20(12): 1461-1464. DOI: 10.1016/j.cclet.2009.07.008 |
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| 作者姓名： | Wei Gang Huang Jing Ya Li Yu Luo Jia Li Wei Lu |
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| 作者单位： | a Department of Chemistry, East China Normal University, Shanghai 200062, China;b The National Center for Drugs Screening, Shanghai Institute of Materia Medica, SIBS, Chinese Academy of Sciences, Shanghai 201203, China |
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| 基金项目： | support by program for New Century Excellent Talents in University (NCET); National Natural Science Foundation of China(No.305722321); Lab of Organic Functional Molecules,the Sino-French Institute of ECNU for supports. |
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| 摘 要： |
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| 关 键 词： | TanshinoneⅡA Cdc25 phosphatases Synthesis Antitumor |
| 收稿时间： | 5 May 2009. |
Synthesis of tanshinone IIA analogues and their inhibitory activities against Cdc25 phosphatases |
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| Wei Gang Huangb,Jing Ya Lib,Yu Luo,Jia Lib,Wei Lua a. Synthesis of tanshinone IIA analogues and their inhibitory activities against Cdc25 phosphatases[J]. Chinese Chemical Letters, 2009, 20(12): 1461-1464. DOI: 10.1016/j.cclet.2009.07.008 |
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| Authors: | Wei Gang Huangb Jing Ya Lib Yu Luo Jia Lib Wei Lua a |
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| Affiliation: | a Department of Chemistry, East China Normal University, Shanghai 200062, China;b The National Center for Drugs Screening, Shanghai Institute of Materia Medica, SIBS, Chinese Academy of Sciences, Shanghai 201203, China |
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| Abstract: | Two series of tanshinone IIA derivatives were synthesized and evaluated for their antitumor activities as Cdc25 phosphatase inhibitors. Most of them demonstrated potent Cdc25 inhibitory activity and powerful cytotoxicity against A549 tumor cell line, producing IC50 values in very low micromolar range. At last, the preliminary SAR was discussed. |
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| Keywords: | Tanshinone IIA Cdc25 phosphatases Synthesis Antitumor |
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