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氟化钠对大鼠血清微量元素的影响
引用本文:刘珊,吴天秀,廖进民,黄连芳,陈艳,陈文双.氟化钠对大鼠血清微量元素的影响[J].广东微量元素科学,2009,16(3):22-26.
作者姓名:刘珊  吴天秀  廖进民  黄连芳  陈艳  陈文双
作者单位:广东医学院广东省天然药物研究与开发重点实验室,广东,湛江,524023
摘    要:为探讨氟化钠(NaF)对大鼠血清四种微量元素含量的影响,将80只2月龄SPF级SD大鼠,雌雄各半,随机分成8组:对照组幼年(CS)、成年(AS)]和用药组幼年高氟(CHS)、成年高氟(AHS)平订幼年低氟(CLS)、成年低氟(ALS)组,长期高氟(HS)和低氟(LS)组];对照组灌胃生理盐水,刖药组分别按相应时阃给予不同剂量的NaF灌胃。结果表明,与CS组相比,CYIS组和CLS组的P分别增加100%(P〈0.05)和193.8%(P〈0.05);与As组相比,HS组的Ca、Zn分别下降了20.5%(P〈0.05)和40%(P〈0.05),而P则增加了74%(P〈0.05),LS组的Zn也下降了33.3%(P〈0.05)。提示:长期使用氟化钠可导致幼年大鼠血中化学元素代谢紊乱。

关 键 词:氟化钠  微量元素  大鼠

Effect of Sodium Fluoride on Trace Elements in Serum of the Rats
LIU Shan,WU Tianxiu,LIAO Jinmin,HUANG Lianfang,CHEN Yan,CHEN Wenshuang.Effect of Sodium Fluoride on Trace Elements in Serum of the Rats[J].Trace Elements Science,2009,16(3):22-26.
Authors:LIU Shan  WU Tianxiu  LIAO Jinmin  HUANG Lianfang  CHEN Yan  CHEN Wenshuang
Institution:Guangdong Key Laboratory for Research and Development of Nature Drugs;Guangdong Medical College;Zhanjiang 524023;China
Abstract:To study the effect of sodium fluoride on the trace elements in the serum of the rats,eighty 2-month-old SPF Sparague-Dawley rats,half male and female,were randomly divided into 8 groups:control(childhood,adult) group and drug-administered group(childhood,adult high-fluoride and low-fluoride group,long-term high-fluoride and low-fluoride group).The control group were administered orally with solution of 0.9% NaCl,while the drug delivery group were given orally with different dose NaF by the corresponding ti...
Keywords:sodium fluoride  trace element  rat  
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