Synthesis of oxovanadium complexes and their apoptosis-inducing activity in leukemia cells |
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| Authors: | Yamaguchi Tomoko Watanabe Shinya Matsumura Yuriko Tokuoka Yoshikazu Yokoyama Akihiro |
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| Affiliation: | Department of Materials and Life Science, Faculty of Science and Technology, Seikei University, 3–3–1 Kichijojikitamachi, Musashino, Tokyo. |
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| Abstract: | Vanadium complexes with different ligands were synthesized and evaluated for antiproliferative activity on U937 cells. The alkyl chain length of the ligands affected the antiproliferative activity, and two complexes-3b and 4-exhibited strong activities with IC(50) values of 6.02 and 3.90 μM respectively. Annexin V staining and DNA ladder formation indicated that these complexes induced apoptosis in U937 cells. |
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