| 关于茎点霉联烯酸丙的绝对构型 |
| |
| 引用本文： | 简亚军,张艳,伍贻康. 关于茎点霉联烯酸丙的绝对构型[J]. 化学学报, 2008, 66(17): 1991-1994 |
| |
| 作者姓名： | 简亚军 张艳 伍贻康 |
| |
| 作者单位： | (中国科学院上海有机化学研究所 生命有机化学国家重点实验室 上海 200032) |
| |
| 基金项目： | 国家自然科学基金，中国科学院知识创新工程项目 |
| |
| 摘 要： | 茎点霉联烯酸丙1是一具全新作用机制的天然抗菌化合物, 其绝对构型在全合成中是从关键中间体炔丙醇4的绝对构型来推定的. 由于后者本身依赖于经验规则, 进一步获取实验证据显得很有必要. 为此我们用Mosher酯法对炔丙醇4的绝对构型进行了测定. 结果表明原先推定的绝对构型是正确的.
|
| 关 键 词： | Mosher酯 对映体 丙炔醇 不对称还原 联烯 |
| 收稿时间： | 2008-02-25 |
| 修稿时间： | 2008-04-28 |
On the Absolute Configuration of Phomallenic Acid C |
| |
| JIAN Ya-Jun,ZHANG Yan,WU Yi-Kang. On the Absolute Configuration of Phomallenic Acid C[J]. Acta Chimica Sinica, 2008, 66(17): 1991-1994 |
| |
| Authors: | JIAN Ya-Jun ZHANG Yan WU Yi-Kang |
| |
| Affiliation: | (State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032) |
| |
| Abstract: | The absolute configuration of phomallenic acid C (1), a recently isolated natural antibiotic with a novel mode of action, was previously established in a total synthesis through deduction from the configura-tion of a key intermediate 4 assigned on an empirical basis. Further experimental evidence is therefore highly desirable. In the present work the absolute configuration of the key propargylic alcohol 4 was deter-mined using the method developed by Mosher. The results show that the previously assigned absolute con-figuration of 1 is correct. |
| |
| Keywords: | Mosher ester enantiomer propargylic alcohol asymmetric reduction allene |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
| 点击此处可从《化学学报》浏览原始摘要信息 |
|
点击此处可从《化学学报》下载全文 |
