Progress on PPAPs cyclization: Guttiferone A as a case study |
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| Authors: | Pauline Menelle Kévin Cottet Yann Fromentin Thomas Gaslonde François-Hugues Porée Didier Buisson Marie-Christine Lallemand |
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| Institution: | 1. Laboratoire de Pharmacognosie, Faculté de Pharmacie de Paris, UMR CNRS 8638 COMETE, Université Paris Descartes Sorbonne Paris Cité, 4 Avenue de l’Observatoire, 75006 Paris, France |
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| Abstract: | Guttiferone A and cyclized analogs are naturally occurring polycyclic polyprenylated acyl phloroglucinols possessing antiparasitic activities. Naturally occurring xanthones possess increased activity, but are either rare or difficult to synthesize. In this paper, three optimized methodologies to access natural, hydroxylated and non-natural xanthonic skeletons from guttiferone A are described. These compounds will serve as starting materials for further SAR studies. |
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| Keywords: | Plant metabolites PPAPs Guttiferone A xanthones Phenolic oxidation |
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