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Transition-metal-free regioselective thiocyanation of phenols,anilines and heterocycles
Authors:Trimbak B Mete  Tushar M Khopade  Ramakrishna G Bhat
Institution:Department of Chemistry, Indian Institute of Science Education and Research (IISER), Pune 411008, Maharashtra, India
Abstract:An expedient direct and regioselective thiocyanation of phenols, anilines and heterocycles is described. Transformation is realized via the direct C/>H functionalization under transition metal free conditions at ambient temperature in excellent yields. Method proved to be monoselective and variety of functional groups tolerated the reaction conditions. The practicality of the protocol is demonstrated in gram scale synthesis of a precursor of PPAR δ agonist in excellent yield.</td>
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Keywords:Thiocyanation  Transition-metal-free  Persulphate  Radical cation  Radical scavenger
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