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N-heterocyclic carbene enabled rhodium-catalyzed ortho C(sp2)-H borylation at room temperature |
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| Authors: | Lei Zhong Zhi-Hong Zong Xi-Cun Wang |
| Institution: | 1. Gansu International Scientific and Technological Cooperation Base of Water-Retention Chemical Functional Materials, College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou, Gansu, 730070, People''s Republic of China;2. Ganzhou District Education Bureau of Zhangye, N0.2 High School of Zhangye, Zhangye, Gansu, 734000, People''s Republic of China |
| Abstract: | We report a rhodium-catalyzed ortho C(sp2)-H borylation of 2-phenylpyridines using commercially available N-heterocyclic carbenes (NHCs) as ligand and pinacolatodiboron (B2pin2) as borylating reagent. The reaction could take place at room temperature, tolerating a wide range of functionalities and affording ortho borylated products in moderate to excellent yields. The current method is also applicable to gram-scale reaction with reduced catalyst loading. |
| Keywords: | Rhodium-catalyzed Ortho borylation N-heterocyclic carbene Room temperature C-H activation |
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