Palladium-catalyzed acetoxylation of arenes by 1,2,3-triazole-directed CH activation |
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| Authors: | Fen Zhao Zhen Chen Xinyuan Ma Shaojun Huang Yubo Jiang |
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| Affiliation: | 1. Faculty of Science, Kunming University of Science and Technology, Jingming South Road 727, Kunming 650500, China;2. Research Center for Analysis and Measurement, Kunming University of Science and Technology, Kunming 650093, China |
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| Abstract: | A facile and efficient method for the regioselective acetoxylation of 1,4-disubstituted 1,2,3-triazoles via Pd-catalyzed CH bond activation was developed. The cheap acetic acid was applied as the acetoxyl source to convert aromatic sp2 CH bonds into CO bonds in high regioselectivity, employing 1,2,3-triazole as an elegant directing group and K2S2O8 as the oxidant. A range of 1,2,3-triazoles bearing acetoxyl group can be synthesized with the reaction facilely. |
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| Keywords: | Palladium 1,4-Disubstituted-1,2,3-triazoles Acetoxylation Regioselectivity |
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