Oxoammonium salt-mediated oxidative nitriles synthesis from aldehydes with ammonium acetate |
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| Authors: | Myeong Jin Kim Junyoung Mun Jinho Kim |
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| Institution: | 1. Department of Chemistry, Incheon National University, 119 Academy-ro, Yeonsu-gu, Incheon 22012, Republic of Korea;2. Department of Energy and Chemical Engineering, Incheon National University, 119 Academy-ro, Yeonsu-gu, Incheon 22012, Republic of Korea |
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| Abstract: | An efficient and scalable route for the synthesis of nitriles was developed by oxoammonium salt (4-acetamido-2,2,6,6-tetramethylpiperidine-1-oxoammonium tetrafluoroborate) mediated oxidative conversion of aldehydes with NH4OAc. A variety of aliphatic aldehydes as well as benzaldehydes were converted into the corresponding nitriles in high yields. The nitroxyl radical which is the reduced species of the used oxoammonium salt was recovered by simple acid-base extraction for the recycling. |
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| Keywords: | Oxoammonium salt Nitriles Ammonium acetate Oxidation Organic synthesis |
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