Two highly selective fluorescence probes for imaging Pd2+ in cells and mice |
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| Authors: | Mei-Pan Yang Bing-Qin Yang Long-Li Kang Li Wang Li-Feng Ma Jing Li Yuan Zhang |
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| Affiliation: | 1. Key Laboratory for Molecular Genetic Mechanisms and Intervention Research on High Altitude Disease of Tibet Autonomous Region, School of Medicine, Xizang Minzu University, Xianyang, 712082 Shaanxi, China;2. Key Laboratory for Basic Life Science Research of Tibet Autonomous Region, School of Medicine, Xizang Minzu University, Xianyang, 712082 Shaanxi, China;3. Key Laboratory of High Altitude Environment and Gene Related to Disease of Tibet Ministry of Education, School of Medicine, Xizang Minzu University, Xianyang, 712082 Shaanxi, China;4. Key Laboratory of Synthetic and Natural Functional Molecule Chemistry, Ministry of Education, College of Chemistry and Materials Science, Northwest University, Xi’an, 710127 Shaanxi, China |
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| Abstract: | Two rhodamine-based probes were designed and prepared, which exhibited highly sensitive and selective fluorescence enhancement upon binding to Pd2+ by UV–vis and fluorescence spectroscopies. Meanwhile the distinct color changes and rapid switch-on fluorescence also provided “naked-eyes” detection for Pd2+ over a broad pH range. The recognition mechanism was explored through Job’s plot, MS data, IR spectra and related theoretical calculations. Furthermore, the probes were applied for biological imaging to confirm that they can be used for monitoring Pd2+ in living cells (L929 and A549 cells) and living mice with satisfying results, which further demonstrated their value of practical applications in environmental and biological systems. |
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| Keywords: | Fluorescent probes Theoretical calculations Living cells and mice |
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