A facile one-pot regioselective synthesis of functionalized novel benzo[f]chromeno[4,3-b][1,7]naphthyridines and benzo[f][1,7]naphthyridines via an imino Diels-Alder reaction |
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| Authors: | Sateesh Kumar Arepalli Byeongwoo Park Jae-Kyung Jung Kiho Lee Heesoon Lee |
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| Affiliation: | 1. College of Pharmacy, Chungbuk National University, Chungbuk 362-763, Republic of Korea;2. College of Pharmacy, Korea University, Sejong 339-700, Republic of Korea |
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| Abstract: | A novel series of functionalized 13H-benzo[f]chromeno[4,3-b][1,7]naphthyridines and 1,3-diphenylbenzo[f][1,7]naphthyridines have been synthesized by an efficient regioselective one-pot multicomponent synthesis through intra and intermolecular imino Diels-Alder reaction. In this method, we have achieved complete regioselectivity and atom economy with polysubstituted core motifs in moderate to good yields. The proposed mechanism of this reaction has also discussed. |
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| Keywords: | Imino Diels-Alder reaction Atom economy One-pot multicomponent reaction |
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