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A facile one-pot regioselective synthesis of functionalized novel benzo[f]chromeno[4,3-b][1,7]naphthyridines and benzo[f][1,7]naphthyridines via an imino Diels-Alder reaction
Authors:Sateesh Kumar Arepalli  Byeongwoo Park  Jae-Kyung Jung  Kiho Lee  Heesoon Lee
Institution:1. College of Pharmacy, Chungbuk National University, Chungbuk 362-763, Republic of Korea;2. College of Pharmacy, Korea University, Sejong 339-700, Republic of Korea
Abstract:A novel series of functionalized 13H-benzof]chromeno4,3-b]1,7]naphthyridines and 1,3-diphenylbenzof]1,7]naphthyridines have been synthesized by an efficient regioselective one-pot multicomponent synthesis through intra and intermolecular imino Diels-Alder reaction. In this method, we have achieved complete regioselectivity and atom economy with polysubstituted core motifs in moderate to good yields. The proposed mechanism of this reaction has also discussed.
Keywords:Imino Diels-Alder reaction  Atom economy  One-pot multicomponent reaction
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