Synthesis of benzimidazoles from o-phenylenediamines and DMF derivatives in the presence of PhSiH3 |
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| Authors: | Jianhua Zhu Zhenbei Zhang Chengxia Miao Wei Liu Wei Sun |
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| Affiliation: | 1. Department of Pharmacy, Nantong University, Nantong, 226000, PR China;2. State Key Laboratory for Oxo Synthesis and Selective Oxidation Suzhou Research Institute of LICP, Lanzhou Institute of Chemical Physics (LICP), Chinese Academy of Sciences, Lanzhou, 730000, PR China;3. University of Chinese Academy of Sciences, Beijing, 100049, PR China |
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| Abstract: | A simple approach to preparation of benzimidazoles from o-phenylenediamines and DMF derivatives, only employing PhSiH3 as promoter without any other additives, was reported. This route provided moderate to high yields with a broad substrate scope. A plausible mechanism for the reaction is proposed based on the spectroscopic characterization (e.g., HRMS and 1H NMR) of the reaction mixture. |
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| Keywords: | Benzimidazoles Cyclization reaction |
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